| Contact Details |
E: Kiaran.Kirk@anu.edu.au
T: (+61 2) 6125 2284
F: (+61 2) 6125 0313 |
| Main Research interests |
Physiology, biochemistry and pharmacology of the malaria parasite.
|
| Teaching Activities |
BIOL1004
: Molecular Biology (Lecturer)
BIOL2174 : Cell Physiology in Health & Disease (Lecturer)
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| Awards |
Roche Medal, 2002 (Australian Society for Biochemistry and
Molecular Biology)
ANU Vice-Chancellor's Award for Excellence in Supervision, 2007
Bancroft-Mackerras Medal, 2008 (Australian Society for Parasitology)
ANU Vice-Chancellor's Citation for Outstanding Contribution to Student Learning, 2008
Australian Teaching and Learning Council: 2009 Citation for Outstanding Contributions to Student Learning
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| Current Research Group |
From left to right:
Rowena Martin - NHMRC Biomedical Fellow
Tegan Dolstra – Hons student
Robert Summers - PhD student
Adele Lehane - PhD student
Laurence Wilson – Hons student
Natalie Spillman - PhD student
Richard Allen - Visiting fellow
Simon Cobbold - PhD student
Rosa Marchetti - PhD student
Kiaran Kirk
Donnelly Van Schalkwyk - Senior Research Officer
| Former PhD Students and Postdocs |
| Former PhD students: |
James Hall, |
James Bursell, |
Henry Staines, |
Rowena Martin, |
Richard Allen, |
Rhys Hayward, |
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Megan Downie, |
Roselani Henry |
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| Former Postdocs: |
Kevin Saliba, |
Ari Karjalainen, |
Lisa Alleva, |
Rongwei Teng |
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| Research |
Malaria is an infectious disease caused by a unicellular microorganism
which, during the course of its lifecycle, invades the red blood cells
of its vertebrate host. The major focus of our research group is
on the physiology and biochemistry of the malaria parasite. We use a combination
of biochemical, molecular and bioinformatic methods to study the mechanisms
by which the parasite acquires nutrients from its host, regulates its
ionic and biochemical composition, and expels potentially harmful metabolic
wastes. We are also investigating the mechanisms underlying the
uptake of, and resistance to, antimalarial drugs. A detailed knowledge
of these various mechanisms will provide the basis for new antimalarial
chemotherapeutic strategies as well as an understanding of mechanisms
of antimalarial drug resistance. |
| Publications |
2010
Allen, R.J.W. and Kirk, K. (2010) Plasmodium falciparum culture: the benefits of shaking. Mol. Biochem. Parasitol., 169, 63-65 [PubMed]
2009
Martin, R.E., Marchetti, R.V., Cowan, A.I., Howitt, S.M., Bröer, S. and Kirk, K. (2009) Chloroquine transport via the malaria parasite’s ‘Chloroquine Resistance Transporter’. Science, 325, 1680-1682 [PubMed]
Martin, R.E., Ginsburg, H. and Kirk, K. (2009) Membrane transport proteins of the malaria parasite. Molec. Microbiol. 74, 519-528 [PubMed]
Dean, S., Marchetti, R., Kirk, K. and Matthews, K.R. (2009) A surface transporter family conveys the differentiation signal in African trypanosomes. Nature, 459, 213-217 [PubMed]
Kirk, K., Howitt, S.M., Bröer. S., Saliba, K.J. and Downie, M.J. (2009) Purine uptake in Plasmodium: transport versus metabolism. Trends in Parasitology, 25, 246-249 [PubMed]
Teng, R., Junankar, P.R., Bubb, W.A., Rae, C., Mercier, P. and Kirk, K. (2009) Metabolite profiling of the intraerythrocytic malaria parasite Plasmodium falciparum by 1H NMR spectroscopy. NMR in Biomedicine, 22, 292-302 [PubMed]
2008
Lehane, A.M. and Kirk, K. (2008) Chloroquine-resistance-conferring mutations in pfcrt give rise to a chloroquine-associated H+ leak from the malaria parasite¹s digestive vacuole. Antimicrob. Agents Chemother, 52, 4374-4380. [PubMed]
Saliba, K.J., Lehane, A.M. and Kirk K. (2008) A polymorphic drug pump in the malaria parasite. Molecular Microbiology, 70, 775-779. [PubMed]
Spillman, N.J., Allen, R.J.W. and Kirk, K. (2008) Acid extrusion from
the intraerythrocytic malaria parasite is not via a Na+/H+
exchanger. Mol. Biochem. Parasitol, 162, 96-99. [PubMed]
Downie, M., Kirk, K. and Ben Mamoun, C. (2008)
Purine salvage pathways in the intraerythrocytic malaria parasite. Eukaryotic Cell, 7, 1231-1237. [PubMed]
Lehane, A.M., Hayward, R., Saliba K.J. and Kirk, K. (2008) A verapamil-sensitive
chloroquine-associated H+ leak from the digestive vacuole of
chloroquine-resistant malaria parasites. J. Cell Science. 121,
1624-1632. [PubMed]
Downie, M.J., Saliba, K.J., Bröer, S., Howitt, S.M. and Kirk, K.
(2008) Purine nucleobase transport in the intraerythrocytic malaria parasite.
Int. J. Parasitol. 38, 203-209. [PubMed]
Spry, C., Kirk, K., Saliba, K.J. (2008) Coenzyme A biosynthesis: an antimicrobial
drug target. FEMS Microbiol. Rev. 32, 56-106. [PubMed]
2007
Henry, R.I., Martin, R.E., Howitt, S.M. and Kirk, K. (2007) Localisation
of a candidate anion transporter to the surface of the malaria parasite.
Biochem. Biophys. Res. Comm. 363, 288-291.
[PubMed]
Lehane, A.M., Marchetti, R.V., Spry, C., van Schalkwyk, D.A., Teng, R.,
Kirk, K. and Saliba K.J. (2007) Feedback inhibition of pantothenate kinase
regulates pantothenol uptake by the malaria parasite. J. Biol. Chem.,
282, 25395-25405. [PubMed]
Staines, H.M., Alkhalil, A., Allen, R.J., De Jonge, H., Derbyshire, E.,
Egee, S., Ginsburg, H., Hill, D.A., Huber, S., Kirk, K., Lang, F., Lisk,
G., Oteng, E., Pillai, A.D., Rayavara, K., Rouhani, S., Saliba, K.J.,
Shen, C., Solomon, T., Thomas, S., Verloo, P., Desai, (2007) Electrophysiological
studies of malaria parasite-infected erythrocytes S.A. International
Journal for Parasitology, 37, 475-482. [PubMed]
Martin, R.E. and Kirk, K. (2007) Transport of the essential nutrient
isoleucine in human erythrocytes infected with the malaria parasite
Plasmodium falciparum. Blood, 109, 2217-2224. [Pubmed]
Kirk, K. and Saliba, K.J. (2007) Targeting nutrient uptake mechanisms
in Plasmodium. Curr. Drug Targets, 8, 75-88. [Pubmed]
2006
Baumeister, S., Winterberg, M., Duranton, C., Huber, S., Lang, F., Kirk,
K. and Lingelbach, K. (2006) Evidence for the involvement of Plasmodium
falciparum proteins in the formation of new permeability pathways
in the erythrocyte membrane. Molec. Micro. 60, 493-504.
[PubMed]
Downie, M.J., Saliba, K.J., Howitt, S.M., Bröer, S. and Kirk, K.
(2006) Transport of nucleosides across the Plasmodium falciparum
parasite plasma membrane has characteristics of PfENT1. Molec.
Micro. 60, 738-748. [PubMed]
Hayward, R., Saliba, K.J. and Kirk, K. (2006) The pH of the digestive
vacuole of Plasmodium falciparum is not associated with chloroquine
resistance. J. Cell Science, 119, 1016-1025. [PubMed]
Saliba, K.J.1, Martin, R.E.1, Bröer, A., Henry,
R.I., McCarthy, C.S., Downie, M.J., Allen, R.J.W., Mullin, K.A., McFadden,
G.I., Bröer, S.2 and Kirk, K.2 (2006)
Sodium-dependent uptake of inorganic phosphate by the intracellular malaria
parasite. Nature
443, 582-585. [1,2: Equal contributions] [PubMed]
2005
Bray, P.G., Martin, R.E., Tilley, L., Ward, S.A., Kirk, K. and Fidock,
D.A. (2005) Defining the role of PfCRT in P. falciparum chloroquine
resistance. Molec. Micro., 56, 323-333 [PubMed]
Hayward, R., Saliba, K.J. and Kirk, K. (2005) Mutations in pfmdr1 modulate the sensitivity of Plasmodium falciparum to the intrinsic
antiplasmodial activity of verapamil. Antimicrob. Agents Chemotherapy,
49, 840-842. [PubMed]
Hayward, R., Saliba, K.J. and Kirk, K. (2005) pfmdr1 mutations
associated with chloroquine resistance incur a fitness cost in Plasmodium
falciparum. Molec. Micro., 55, 1285-1295. [PubMed]
Kirk, K., Martin, R.E., Bröer, S., Howitt, S.M. and Saliba, K.J.
(2005) Plasmodium Permeomics: Membrane transport proteins in
the malaria parasite. Current Topics in Microbiology and Immunology: Malaria (S. Krishna and D. Sullivan, eds), 295, 325-356. [PubMed]
Martin, R.E., Henry, R.I., Abbey, J.L., Clements, J.D, and Kirk, K.
(2005) The 'permeome' of the malaria parasite: an overview of the membrane
transport proteins of Plasmodium falciparum. Genome Biology, 6, R26.
Saliba, K.J., Ferru, I. and Kirk, K. (2005) Pro-vitamin B5 (pantothenol)
inhibits the growth of the intraerythrocytic malaria parasite. Antimicrob.
Agents Chemotherapy, 49, 632-637. [PubMed]
Saliba, K.J. and Kirk, K. (2005) CJ-15,801, a fungal natural product,
inhibits the intraerythrocytic stage of Plasmodium falciparum in
vitro via an effect on pantothenic acid utilisation. Molec.
Biochem. Parasitol., 141, 129-131. [PubMed]
Spry, C., Chai, C.L.L., Kirk, K., Saliba, K.J. (2005) A class of pantothenic
acid analogs inhibits Plasmodium falciparum pantothenate kinase
and represses the proliferation of malaria parasites, Antimicrob.
Agents Chemother., 49, 4649-4657. [PubMed]
2004
Allen, R.J.W. and Kirk, K. (2004) The membrane potential of the intraerythrocytic
malaria parasite, Plasmodium falciparum. J. Biol. Chem.,
279, 11264-11272. [PubMed]
Allen, R.J.W and Kirk K. (2004) Cell volume control in the Plasmodium-infected
erythrocyte. Trends in Parasitology, 20, 7-10. [PubMed]
Becker, K and Kirk, K. (2004) Of malaria, metabolism, and membrane
transport. Trends in Parasitology, 20, 590-596. [PubMed]
Go, M-L., Liu, M., Wilairat, P., Rosenthal, P.J., Saliba, K.J. and
Kirk, K. (2004) Anti-plasmodial chalcones inhibit sorbitol-induced hemolysis
of Plasmodium falciparum-infected erythrocytes. Antimicrob.
Agents Chemotherapy, 48, 3241-3245.[PubMed]
Junankar, P.R., Karjalainen, A. and Kirk, K. (2004) Osmotic swelling
activates two pathways for K+ efflux in rat hepatoma cell
line. Cellular Physiol. Biochem., 14, 143-54. [PubMed]
Kirk, K. (2004) Channels and transporters as drug targets in the Plasmodium-infected
erythrocyte. Acta Tropica, 89, 285-298. [PubMed]
Lehane, A.M., Saliba, K.J., Allen, R.J.W. and Kirk, K. (2004) Choline
uptake into the malaria parasite is energized by the membrane potential. Biochem. Biophys. Res. Comm., 320, 311-317. [PubMed]
Lingelbach, K., Kirk, K., Rogerson, S., Langhorne, J., Carucci, D.J.
and Waters, A. (2004) Molecular approaches to malaria. Molec. Micro.,
54, 575-587. [PubMed]
Martin, R.E. and Kirk, K. (2004) The malaria parasite's chloroquine
resistance transporter is a member of the drug/metabolite transporter
superfamily. Molecular Biology and Evolution, 21: 1938-1949.
[PubMed]
Saliba, K.J., Krishna, S. and Kirk, K. (2004) Inhibition of hexose
transport and abrogation of pH homeostasis in the intraerythrocytic
malaria parasite by an O-3-hexose derivative. FEBS Lett., 570,
93-96. [PubMed]
Staines, H.M., Dee, B.C., O'Brien, M., Lang, H., Englert, H., Horner,
H.A., Ellory, J.C. and Kirk, K. (2004) Furosemide analogues as potent
inhibitors of the new permeability pathways of Plasmodium falciparum-infected
human erythrocytes. Molec. Biochem. Parasitol., 133, 171-174. [PubMed]
2003
Baumeister, S., Endermann, T., Charpian, S., Nyalwidhe, J. Duranton,
C., Huber, S., Kirk, K., Lang, F. and Lingelbach, K. (2003) A biotin
derivative blocks parasite induced novel permeation pathways in Plasmodium
falciparum-infected erythrocytes. Molec. Biochem. Parasitol.,
132, 35-45.
Kirk, K. (2003) Ion channels in the ‘malaria-infected’
infected red blood cell. Physiology News 51, 17-19.
Kirk, K. and Saliba, K.J. (2003) The membrane physiology of the ‘malaria-infected’
red cell, in Red Cell Membrane Transport in Health and Disease
(I. Bernhardt and J.C. Ellory, eds) pp 569-585, Springer, Berlin.
Saliba, K. J., Allen, R. J., Zissis, S., Bray, P. G., Ward, S. A.,
Kirk, K. (2003) Acidification of the malaria parasite's digestive vacuole
by a H+-ATPase and a H+-pyrophosphatase. J.
Biol. Chem., 278, 5605-5612.
2002
Bray, P.G., Saliba, K.J., Davies, J.D., Spiller, D.G., White, M.R.H.,
Kirk, K. and Ward, S.A. (2002) Distribution of acridine orange fluorescence
in Plasmodium falciparum-infected erythrocytes and its implications
for the evaluation of digestive vacuole pH. Molec. Biochem.Parasitol.,
119, 301-304.
Bray, P.G., Saliba, K.J., Davies, J.D., Spiller, D.G., White, M.R.H.,
Kirk, K. and Ward, S.A. (2002) A further comment on the distribution
of acridine orange fluorescence in Plasmodium falciparum-infected
erythrocytes. Molec. Biochem. Parasitol., 119, 311-313.
Junankar, P.J., Karjalainen, A. and Kirk, K. (2002) The role of P2Y1
purinergic receptors and cytosolic Ca2+ in hypotonically-activated
osmolyte efflux from a rat hepatoma cell line. J. Biol. Chem.,
277, 40324-40334.
2001
Alleva, L.M. and Kirk, K. (2001) Calcium regulation in the intracellular
malaria parasite. Molec. Biochem. Parasitol. 117, 121-128.
Biagini, G. A., Knodler, L. A., Saliba, K.J., Kirk, K. and Edwards,
M. R. (2001) Na+ dependent pH regulation by the microaerophilic
parasite Giardia intestinalis. J. Biol. Chem., 276,
29157-29162.
Elliott, J.L., Saliba, K.J. and Kirk, K. (2001) Transport of lactate
and pyruvate in the intraerythrocytic malaria parasite, Plasmodium
falciparum. Biochem. J., 355, 733-739.
Kirk, K. (2001) Membrane transport in the malaria-infected erythrocyte. Physiol. Rev. 81, 495-537.
Kirk, K. (2001) Malaria: A voracious creature, Lancet, 358
(Suppl.), 41.
Kirk, K. and Saliba, K.J. (2001) Chloroquine resistance and the pH
of the malaria parasite’s digestive vacuole. Drug Resistance
Updates, 4, 335-337.
Saliba,K.J. and Kirk, K. (2001) H+ coupled pantothenate
transport in the intracellular malaria parasite, Plasmodium falciparum. J.Biol.Chem., 276, 18115-18121.
Staines, H.M, Ellory, J.C. and Kirk, K. (2001) Perturbation of the
pump-leak balance for Na+ and K+ in malaria-infected
erythrocytes. Am.J. Physiol. (Cell), 280, C1576-C1587.
Saliba, K.J. and Kirk, K. (2001) Nutrient acquisition by intracellular
apicomplexan parasites: Staying in for dinner. Int. J. Parasitol., 31, 1321-1330.
2000
Biagini, G.A., Kirk, K., Schofield, P.J. and Edwards, M.R. (2000) Role
of K+ and amino acids in osmoregulation by the free-living
microaerophilic protozoon Hexamita inflata. Microbiology,
146, 427-433.
Biagini, G.A., Lloyd, D. Kirk, K. and Edwards, M.R. (2000) The membrane
potential of Giardia intestinalis. FEMS Microbiol. Letters,
192, 153-157.
Junankar, P.R. and Kirk, K. (2000) Organic osmolyte channels: a comparative
view. Cell Physiol. Biochem. 10, 355-360.
Kirk, K. (2000) Malaria: Channeling nutrients. Nature, 406,
949-950.
Krishna, S.J., Woodrow, C., Burchmore, R., Saliba, K.J. and Kirk, K.
(2000) Hexose transport in asexual stages of Plasmodium falciparum and Kinetoplastidae. Parasitology Today 16, 516-521.
Reed, M.B., Saliba, K.J., Caruana, S.R., Kirk, K. and Cowman, A.F.
(2000) Pgh1 modulates sensitivity and resistance to multiple antimalarials
in Plasmodium falciparum. Nature, 403, 906-909.
Staines, H.M., Rae, C. and Kirk, K. (2000) Increased permeability of
the malaria-infected erythrocyte to organic cations, Biochim. Biophys.
Acta, 1463, 88-98.
1999
Kirk, K., Staines, H.M., Martin, R.E. and Saliba, K.J. (1999) Transport
properties of the host cell membrane, in Transport and Trafficking
in the Malaria-Infected Erythrocyte, Wiley, Chichester (Novartis
Foundation Symposium 226) pp 55-73.
Kirk, K., Tilley, L. and Ginsburg, H. (1999) Transport and Trafficking
in the Malaria-Infected Erythrocyte. Parasitology Today 15,
355-357.
Rickards, R.W., Rothschild, J.M., Willis, A.C., de Chazal, N.M., Kirk,
J., Kirk, K., Saliba, K.J. and Smith, G.D. (1999) Calothrixins A and
B, novel pentacyclic metabolites from Calothrix cyanobacteria with potent
activity against malaria parasites and human cancer cells. Tetrahedron,
55, 13513-13520.
Staines, H.M., Chang, W., Ellory, J.C., Tiffert, T., Kirk, K. and
Lew, V.L. (1999) Passive Ca2+ transport and Ca2+-
dependent K+ transport in Plasmodium falciparum-infected
red cells. J. Membr. Biol. 172. 13-24.
Saliba, K.J. and Kirk, K. (1999). pH regulation in the intracellular
malaria parasite, Plasmodium falciparum: H+extrusion
via a V-Type H+-ATPase. J. Biol. Chem., 274, 33213-33219.
Saliba, K.J., Martin, R.E., Staines, H.M. and Kirk, K. (1999) A novel
anion channel in the malaria-infected erythrocyte: opportunities for antimalarial
chemotherapy, in Chloride Channels (R.Z. Kozlowski, ed.).
Isis Medical Media, pp 137-148.
1998
Ginsburg, H. and Kirk, K. (1998) Membrane transport in the malaria-infected
erythrocyte, In Malaria: Parasite Biology, Pathogenesis, Protection
(I.W. Sherman, ed.) pp 219-232.
Kirk,K. and Strange, K. (1998) Functional properties and physiological
roles of organic solute channels. Ann. Rev. Physiol., 60, 719-739.
Saliba, K.J. and Kirk, K. (1998) Clotrimazole inhibits the growth of Plasmodium falciparum in vitro. Proc. Roy. Soc. Trop. Med.
Hyg. 92, 666-667.
Staines, H.M. and Kirk, K. (1998) Increased choline transport in erythrocytes
from mice infected with the malaria parasite Plasmodium vinckei
vinckei. Biochem. J. 334, 525-530.
Saliba, K.J., Horner, H.A. and Kirk, K. (1998) Transport and metabolism
of the essential vitamin pantothenic acid in human erythrocytes infected
with the malaria parasite Plasmodium falciparum. J. Biol.
Chem., 273, 10190-10195.
1997
Kirk, K. (1997) Swelling-activated osmolyte channels. J. Membr.
Biol. 158, 1-16.
1996
Bursell, J.D.H. and Kirk, K. (1996) Swelling-activated K+ transport via two functionally distinct pathways in eel erythrocytes. Am. J. Physiol. 270, R61-R70.
Bursell, J.D.H., Kirk, J., Hall. S.T., Gero, A.M. and Kirk, K. (1996) Volume-regulatory amino acid release from the protozoan parasite Crithidia luciliae. J. Membr. Biol. 154, 131-141.
Hall, J.A., Kirk, J., Potts, J.R., Rae, C. and Kirk, K. (1996) Anion channel blockers inhibit swelling-activated anion, cation and nonelectrolyte transport in HeLa cells. Am. J. Physiol. 271, C579-C588.
Kirk, K., Horner, H.A. and Kirk, J. (1996) Glucose uptake in Plasmodium falciparum-infected erythrocytes is an equilibrative not an active process. Molec. Biochem. Parasitol. 82, 195-205.
Lewis, R.A., Bursell, J.D.H. and Kirk, K. (1996) Anion-selectivity of the swelling-activated osmolyte channel in eel erythrocytes. J. Membr. Biol. 149, 103-111.
1995
Basavappa, S., Chartouni, V., Kirk, K., Prpic, V., Ellory, J.C., and Mangel, A.W. (1995) Swelling‑induced chloride currents in neuroblastoma cells are calcium dependent. J. Neurosci. 15, 3662-3666.
Kirk, K. and Horner, H.A. (1995) In search of a selective inhibitor of the induced transport of small solutes in Plasmodium falciparum-infected erythrocytes: effects of arylaminobenzoates. Biochem. J. 311, 761-768.
Kirk, K. and Horner, H.A. (1995) Novel anion dependence of induced cation transport in malaria-infected erythrocytes. J. Biol. Chem. 270, 24270-24275.
1994
Gero, A.M. and Kirk, K. (1994) Nutrient transport pathways in Plasmodium-infected erythrocytes: what and where are they? Parasitology Today, 10, 395-399.
Joyner, S.E. and Kirk, K. (1994) Two pathways for choline transport in eel erythrocytes: a saturable carrier and a volume-activated channel. Am. J. Physiol. 267, R773-R779.
Kirk, J. and Kirk, K. (1994) Inhibition of volume-activated I- and
taurine efflux from HeLa cells by P-glycoprotein inhibitors correlates
with calmodulin inhibition. J. Biol. Chem. 269, 29389-29394.
Kirk, K., Horner, H.A., Elford, B.C., Ellory, J.C. and Newbold, C.I. (1994) Transport of diverse substrates into malaria-infected erythrocytes via a pathway showing functional characteristics of a chloride channel. J. Biol. Chem. 269, 3339-3347.
Kuchel, P.W., Kirk, K. and King, G.F. (1994) NMR Methods for measuring membrane transport. Subcellular Biochemistry 23 (Physico-Chemical Methods in the Study of Biomembranes) 247-327.
Vandenberg, J.I., Yoshida, A., Kirk, K. and Powell, T. (1994) Swelling-activated and isoprenaline‑activated chloride currents in guinea pig cardiac myocytes have distinct electrophysiology and pharmacology. J. Gen. Physiol. 104, 997-1017.
1993
Kirk, K. and Kirk, J. (1993) Volume-regulatory taurine release from a human lung cancer cell line: evidence for amino acid transport via a volume-activated chloride channel. FEBS Lett. 336, 153-158.
Kirk, K., Horner, H.A., Spillett, D.J. and Elford, B.C. (1993) Glibenclamide and meglitinide block the transport of low molecular weight solutes into malaria-infected erythrocytes. FEBS Lett. 323, 123-128.
1992
Ellory, J.C., Kirk, K., Culliford, S.J., Nash, G.B., Stuart, J. (1992) Nitrendipine is a potent inhibitor of the Ca2+-activated K+ channel of human erythrocytes. FEBS Lett. 296, 219-221.
Kirk, K., Ellory, J.C. and Young, J.D. (1992) Transport of organic substrates via a volume-activated channel. J. Biol. Chem. 267, 23475-23478.
Kirk, K., Figueiredo, P.C., Elford, B.C. and Ellory, J.C. (1992) Effect of cell age on erythrocyte choline transport: implications for the increased choline permeability of malaria-infected erythrocytes. Biochem. J. 283, 617-619.
Kirk, K., Elford, B.C. and Ellory, J.C. (1992) The enhanced K+ leak of malaria-infected erythrocytes is not via a Ca2+-activated K+ channel. Biochim. Biophys. Acta 1135, 8-12.
1991
Kirk, K. (1991) K+ transport across the lamprey erythrocyte membrane: characteristics of a Ba2+-and amiloride-sensitive pathway. J. Exp. Biol. 159, 303-324.
Kirk, K. (1991) The effect of N-ethylmaleimide on K+ and Cl- transport pathways in the lamprey erythrocyte membrane: activation of KCl cotransport. J. Exp. Biol. 159, 325-334.
Kirk, K., Ashworth, K.J., Elford, B.C., Pinches, R.A. and Ellory, J.C. (1991) Characteristics of 86Rb+ transport in human erythrocytes infected with Plasmodium falciparum. Biochem. Biophys. Acta 1061, 305-308.
Kirk, K., Wong, H.Y., Elford, B.C., Newbold, C.I. and Ellory, J.C. (1991) Choline and Rb+ transport in human erythrocytes infected with Plasmodium falciparum. Biochem. J. 278, 521-525.
1990
Kirk, K. (1990) NMR methods for measuring membrane transport rates. NMR in Biomedicine 3, 1-16.
1989
Potts, J.R., Kirk, K. and Kuchel, P.W. (1989) Characterisation of the transport of the non-electrolyte dimethyl methylphosphonate across the red cell membrane, NMR in Biomedicine 1, 198-204.
1988
Bubb, W.A., Kirk, K. and Kuchel, P.W. (1988) Ethylene glycol as an X-nucleus thermometer for biological samples. J. Magn. Reson. 77, 363-368.
Kirk, K. and Kuchel, P.W. (1988) The contribution of magnetic susceptibility effects to transmembrane chemical shift differences in the 31P NMR spectra of oxygenated erythrocyte suspensions. J. Biol. Chem. 263, 130-134.
Kirk, K., Kuchel, P.W. and Labotka, R.J. (1988) The hypophosphite ion as a 31P NMR probe of membrane potential in erythrocyte suspensions. Biophys. J. 59, 241-247.
Kirk, K. and Kuchel, P.W. (1988) Characterization of transmembrane chemical shift differences in the 31P NMR spectra of various phosphoryl compounds in erythrocyte suspensions. Biochemistry 27, 8795-8802.
Kirk, K. and Kuchel, P.W. (1988) Physical basis of the effect of hemoglobin on the 31P NMR chemical shifts of various phosphoryl compounds. Biochemistry 27, 8803-8810.
1987
Kuchel, P.W., Bulliman, B.T., Chapman, B.E. and Kirk, K. (1987) The use of transmembrane differences in saturation transfer for measuring fast membrane transport: application to H13CO3- exchange across the human erythrocyte. J. Magn. Reson. 74, 1-11.
Raftos, J.E., Kirk, K. and Kuchel, P.W. (1987) Further investigation of the use of dimethyl methylphosphonate as a 31P NMR probe of red cell volume. Biochim. Biophys. Acta 968, 160-166.
1986
Chapman, B.E., Kirk, K. and Kuchel, P.W. (1986) Bicarbonate exchange kinetics at equilibrium across the erythrocyte membrane by 13C NMR. Biochem. Biophys. Res. Comm. 136, 266-272.
Kirk, K. and Kuchel, P.W. (1986) Equilibrium exchange of dimethyl methylphosphonate across the human red cell membrane measured using NMR spin transfer. J. Magn. Reson. 68, 311-318.
Kirk, K., Raftos, J.E. and Kuchel, P.W. (1986) Triethyl phosphate as an internal 31P NMR reference in biological samples. J. Magn. Reson. 70, 484-487.
Stewart, I.M., Chapman, B.E., Kirk, K., Kuchel, P.W., Lovric, V.A. and Raftos, J.E. (1986) intracellular pH in stored erythrocytes. Refinement and further characterisation of the 31P NMR methylphosphonate procedure. Biochim. Biophys. Acta 885, 23-33.
1985
Kirk, K. and Kuchel, P.W. (1985) Red cell volume changes monitored using a new 31P NMR procedure. J. Magn. Reson. 62, 568-572. |
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